Jacob Glanville, CSO

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Jake grew up in a village in the highlands of Guatemala, but returned to the first world to solve problems in computational immunology. He went from the Tzutujile village of Santiago Atitlan in Guatemala to an undergraduate in Genetics, Genomics and Development research at UC Berkeley, to become Principal Scientist at Pfizer, to entering into and in the process of completing a PhD in Computational and Systems Immunology at Stanford University School of Medicine, and now Chief Science Officer and Co-founder of Distributed Bio.

He is a field leader in antibody, TCR and pMHC repertoire algorithms and methods development, having published multiple early defining manuscripts and patents to combine next generation sequencing, protein engineering, immunology, and algorithm development to interrogate antibody repertoires and optimize their responses towards therapeutic applications. He personally developed the core algorithms that allowed Distributed Bio to become profitable within the first year of founding, with clients and collaborators now including 7 of the top 10 pharma, multiple research institutions, the Stanford Hospital Blood and Marrow transplant clinic and over 30 biotechnology and academic institutions internationally.

As a UC Berkeley undergraduate, Jacob Glanville performed research in two academic laboratories, Dr. Glenys Thomson's HLA Population Genetics laboratory, and Dr. Sjolander's Berkeley Phylogenomics Group, where in the latter, as an undergrad, he begin publishing first-author publications. In March 2008, Jacob was recruited to Pfizer's Rinat Antibody Therapeutics research facility, he developed novel computational immunology methods for characterizing and optimizing functions of the adaptive immune system, engineering molecules for drug development, and was promoted every year for four consecutive years to become Principal Scientist by 2012. In 2012 he left Pfizer with a vision to create Distributed Bio and bring routine antibody repertoire analytics to the masses.

In parallel with co-leading the now-profitable Distributed Bio, he is working to complete a PhD in Computational and Systems Immunology at Stanford University, coadvised by Mark Davis and Scott Boyd and in collaboration with multiple other laboratories including the Nadeau, Maecker, Martinez, Engleman, and Chien labs.

Publication

J Glanville*, T Kuo*, HC von Budingen* et al, "Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation",Proceedings of the National Academy of Sciences, 2011

W Zhai*, J Glanville* et al, "Synthetic antibodies designed on natural sequence landscapes", Journal of Molecular Biology, 2011

J Glanville*, W Zhai*, J Berka* et al, "Precise determination of the diversity of the combinatorial library gives insight into the human immunoglobulin repertoire," Proceedings of the National Academy of Sciences, 2009

J Glanville et al, "Berkeley Phylogenomics Group web servers: resources for structural phylogenomic analysis", Nucleic acids research, 2007

M Birnbaum, et al. "Deconstructing the Peptide-MHC Specificity of T Cell Recognition." Cell 157.5 (2014): 1073-1087.

A Han, J Glanville et al. "Linking T-cell receptor sequence to functional phenotype at the single-cell level." Nature biotechnology (2014).

HV Bùˆdingen, T Kuo, S Marina, C Belle, L Apeltein, J Glanville et al. "B cell exchange across the blood-brain barrier in multiple sclerosis." The Journal of Clinical Investigation 122.12 (2012): 4533.

C Mahon, M Lamburt, J Glanville, et al. "Comprehensive interrogation of a minimalist synthetic CDR-H3 library and its ability to generate antibodies with therapeutic potential." Journal of Molecular Biology (2013).

J Benichou, J Glanville et al. "The Restricted DH Gene Reading Frame Usage in the Expressed Human Antibody Repertoire Is Selected Based upon its Amino Acid Content." The Journal of Immunology 190.11 (2013): 5567-5577.

A Han, E Newell, J Glanville, et al. "Dietary gluten triggers concomitant activation of CD4+ and CD8+ T cells and g/d T cells in celiac disease." Proceedings of the National Academy of Sciences 110.32 (2013): 13073-13078.

S D’Angelo, J Glanville, et al. "The antibody mining toolbox: An open source tool for the rapid analysis of antibody repertoires." mAbs. Vol. 6. No. 1. Landes Bioscience, 2013.

Liberman, Gilad, et al. "Multi step selection in Ig H chains is initially focused on CDR3 and then on other CDR regions." Frontiers in immunology 4 (2013).

Liberman, Gilad, et al. "Estimate of Within Population Incremental Selection Through Branch Imbalance in Lineage Trees." bioRxiv (2014).

Jackson, Katherine JL, et al. "Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements." Cell host & microbe 16.1 (2014): 105-114.

Qi, Qian, et al. "Diversity and clonal selection in the human T-cell repertoire." Proceedings of the National Academy of Sciences 111.36 (2014): 13139-13144.

Patent

A RAJPAL, D STONE, J GLANVILLE, W ZHAI. "ANTI-NOTCH-1 ANTIBODIES and uses thereof"

D FOLETTI, J RIGGERS, J GLANVILLE, ET AL. "STAPHYLOCOCCUS AUREUS SPECIFIC ANTIBODIES AND USES THEREOF."

J GLANVILLE. "EPITOPE FOCUSING THROUGH VARIABLE SURFACE CONCENTRATION ENSEMBLES"


Exposition

2015 Speaker: Protein Engineering Summit (PEGS) 
2015 Speaker: PepTalk Antibody Engineering
2014 Speaker: IBC
2014 Speaker: IRMACS
2014 Speaker: Harvard Ragon Institute
2014 Speaker: Next Generation Protein Therapeutics (IBC)
2014 Speaker: Protein Engineering Summit (PEGS)
2014 Instructor: Stanford Systems Immunology 206a
2014 Speaker: Gordon Antibody Biology and Engineering
2014 Guest Lecturer: Stanford Advanced Immunology 201
2013 Guest Lecturer: Stanford Computational Immunology 310
2013 Speaker: Antibody Engineering and Therapeutics (IBC)
2013 Speaker: Protein Engineering Summit (PEGS)
2013 Speaker: Stanford Immunology Asilomar Retreat
2013 Speaker: Molecular Medicine Tri-CON
2013 Speaker: Molecular Medicine Tri-CON Short course
2012 Speaker: Antibody Engineering/Antibody Therapeutics IBC
2012 Speaker: Stanford Photonics Research Center Symposium
2012 Speaker: Next Generation Sequencing Conference, Prague
2012 Speaker: Drug Discovery and Development Leaders Summit
2012 Speaker: Antibody Design and Discovery Conference
2012 Speaker: Protein Engineering Summit (PEGS)
2012 Speaker: Molecular Medicine Tri-CON
2011 Speaker: Copenhagenomics
2011 Speaker: 4th Protein Therapeutic Discovery Conference
2010 Speaker: 20th World Molecular Engineering Network
2010 Speaker: X-Gen Congress
2010 Speaker: Molecular Medicine Tri-CON
2006 Speaker: California Metagenomics workshop
2006 Speaker: Transkingdom Innate Immunity Workshop: host team
2006 Speaker: Cytoscape workshop